10 Most Dangerous Drugs Prescribed By Doctors Fentanyl. If used properly, opioids can play an important role in pain management. Oxycodone. Oxycodone (which is featured in such brand-name drugs as Oxycontin and Percocet) can, like fentanyl, provide pain relief to those who need it most. Methadone. Warfarin. Statins. Alprazolam. Anabolic Androgenic Steroids. Methotrexate.