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What is the best medication for acid reflux?

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The proton-pump inhibitors esomeprazole (Nexium 24HR), lansoprazole (Prevacid 24HR), and omeprazole (Prilosec OTC) are sold over-the-counter to treat frequent heartburn (two or more times per week) for 14 days. These types of medicines are also available as higher-strength prescriptions.
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